Do you provide cGMP-grade peptides?
cGMP peptide development and synthesis is the core of our business. LexinPharma provides large-scale cGMPpeptide services with capacity up to 100 kilograms per project. Our comprehensive experience and capacity forcGMP-grade synthesis of new chemical entities (NCEs) or generic peptides (G-Rx) is uni
Continue ReadingWhat is the maximum peptide length you can synthesize?
We can synthesize peptides of lengths up to ~80 residues. Peptide lengths of 10 to 70 residues can usually bemade by direct solid phase peptide synthesis (SPPS) chemical synthesis. Depending upon the scale and futurerequirements, combined strategies of using solution fragment condensation or even hy
Continue ReadingWhat causes delays in peptide delivery?
Peptide production is unpredictable because every peptide sequence is unique. Each has specific characteristicsdepending upon the residues present and the difficulties which they may present. Unfortunately, this can result indelays in delivery as we must fine-tune a successful process and to prevent
Continue ReadingWhat methods do you use to synthesize peptides?
We typically use Fmoc-tBu solid-phase peptide synthesis (SPPS), but we are also very skilled in the art of classical(solution phase or liquid phase peptide synthesis (LPPS)), and hybrid synthesis methods. Hybrid synthesistechnology utilizes fully protected peptide fragments that are coupled onto res
Continue ReadingWhat is the best way to dissolve peptides?
The solubility of a given peptide varies depending on its amino acid sequence and modifications. LexinPharmapurifies peptides by RP-HPLC using a water and acetonitrile gradient. Here are some general tips for dissolvingpeptides:Sonication increases solubility. 10% acetic acid in the solvent will hel
Continue ReadingHow should you store peptides?
We recommend that lyophilized peptides be stored long-term at -20°C. For peptides containing oxidation sensitiveresidues such as Cys, Met or Trp, we recommend storing under an inert atmosphere of N2 as well.
Continue ReadingHow is theoretical net peptide content calculated?
Theoretical net peptide content (calculated assuming that counterions are the only non-peptide components presentin your peptide sample) can be estimated by dividing molecular weight (MW) of the peptide by a sum of thismolecular weight and a number of trifluoroacetate (TFA) or acetate (AcO-) counter
Continue ReadingWhat is net peptide content?
It is important to understand the difference between net peptide content and total (gross) peptide content. Thelyophilized peptide powder shipped to you usually contains not only peptide, but also some other substances suchas water, adsorbed solvents, counterions and salts. The total peptide content
Continue ReadingWhat peptide purification methods do you use?
Theoretical net peptide content (calculated assuming that counterions are the only non-peptide components present in your In most cases, we use preparative RP-HPLC for peptide purification. Occasionally, ion exchange chromatography (IEX) may be utilized as well. IEX is particularly useful in the cas
Continue ReadingWhat is the typical purity percentage of custom peptides?
At LexinPharma, the purity percentage of custom peptides is set by our partner’s specification. Typically, manyresearchers choose >95% by reverse-phase High Performance Liquid Chromatography (RP-HPLC or rHPLC). Thismeans that 95% of the NET PEPTIDE content (but not the total peptide content, see
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