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What is the maximum peptide length you can synthesize?

We can synthesize peptides of lengths up to ~80 residues. Peptide lengths of 10 to 70 residues can usually be

made by direct solid phase peptide synthesis (SPPS) chemical synthesis. Depending upon the scale and future

requirements, combined strategies of using solution fragment condensation or even hybrid methods involving solid- phase couplings of protected peptide fragments may be developed specifically for each product. We also can utilize

native chemical ligation (NCL) to make longer peptides and potentially mini-proteins using fully deprotected peptide

fragments with an N-terminal Cys residue and another fragment containing a C-terminal thioester. While we have

successfully manufactured peptides >80 residues, peptides greater than 80 amino acids are often more viably

manufactured via a recombinant synthesis. On the other hand, peptides with 2-10 amino acids are often

manufactured by solution or liquid phase peptide synthesis (LPPS).